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Male sexual dysfunction is one of the most common health problems affecting men and is more common with increasing age. Chronic ED affects about 5% of men in their 40s and 15-25% of men by the age of 65. Transient ED and inadequate erection affect as many as 50% of men between the ages of 40 and 70. In around 95% of the cases, a suitable treatment can be found. Erectile dysfunction is treatable at any age, and awareness of this fact has been growing. More men have been seeking help and returning to normal sexual activity because of improved, successful treatments for erectile dysfunction. Viagra, Levitra and Cialis Currently, there are three oral medications approved by the Food and Drug Administration (FDA) for the treatment of erectile dysfunction: sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis). All these agents block the enzyme phosphodiesterase type 5 (PDE-5) and belong to a class of drugs called phosphodiesterase (PDE) inhibitors. Viagra was the first and is probably the most famous of the three PDE-5 inhibitors used to treat erectile dysfunction. Viagra was approved as an effective agent for treating erectile dysfunction in March 27, 1998. Viagra is manufactured by Pfizer, Inc. Levitra was the second PDE-5 inhibitor to come to market in the United States, and it was approved by the FDA in August 19, 2003. Levitra is manufactured by Bayer Pharmaceuticals Corporation. Cialis was the third PDE-5 inhibitor to come to market and was approved by the FDA at the end of November 21, 2003. Cialis is manufactured by Lilly ICOS LLC. The major advantage of PDE-5 inhibitors is that they do not cause an erection at inappropriate times, because they act only in response to sexual stimulation. If there is no sexual stimulation drug remains in the background. All three are taken orally prior to planned sexual activity, acting to increase blood flow in the penis in response to sexual stimulation. However, there are important differences between the three, differences that could influence safety, specificity, duration of action, adverse effects, and ultimately, public acceptance within this class of drug. Mechanism of Action PDE-5 inhibitors do not directly cause an erection of the penis, but they alter the body's response to sexual stimulation by enhancing the effect of the nitric oxide, a chemical that is normally released during stimulation. Nitric oxide causes relaxation of the muscles in the penis, which allows for better blood flow to the penile area. Effectiveness of PDE-5 Inhibitors All 3 PDE-5 inhibitors have demonstrated excellent efficacy. Viagra, at 84%, is slightly more effective than Cialis at 81% and Levitra at 80%. Pharmaceutical Forms, Onset of Action and Duration of Effect Viagra and Levitra differ only minimally in terms of their structure, while Cialis differs markedly from Viagra and Levitra in terms of its molecular structure, which is also reflected in pharmacokinetic differences. Viagra: 25 mg, 50 mg 100 mg tablets Onset of action: 30 minutes (effect delayed if taken with food) Duration of action: 4 to 5 hours Levitra: 2.5 mg, 5 mg, 10 mg, 20 mg tablets Onset of action: 25 minutes (effect delayed by fatty meal) Duration of action: 4 to 5 hours Cialis: 5 mg, 10 mg, 20 mg tablets Onset of action: 16-45 minutes (effect NOT delayed by food) Duration of action: 36 hours All three drugs require sexual stimulation to be effective. Viagra should be taken on an empty stomach it works better if you do not eat a high-fat meal around the time you take it. Levitra may be slightly less effective if you eat a high-fat meal, but a moderate-fat meal does not reduce its effectiveness. Cialis works without regard to what you eat. Viagra and Levitra have similar half-lives, and onset and duration of action. Cialis has a slower onset of action and longer duration of action, which is attributed to its longer half-life. Patients who wish for spontaneity may opt for Cialis, which may allow for successful intercourse up to 36 hours postdose, even though it takes longer to reach peak effect. The considerably longer duration of effect for Cialis will likely allow less frequent dosing and greater impulsiveness between partners, but also could potentially prolong adverse effects. Dosage The recommended dose for Viagra is 50 mg, and the physician may adjust this dose to 100 mg or 25 mg, depending on the patient. The recommended dose for either Levitra or Cialis is 10 mg, and the physician may adjust this dose to 20 mg if 10 mg is insufficient. A lower dose of 5 mg is available for patients who take other medicines or have conditions that may decrease the body's ability to use the drug. Levitra is also available in a 2.5 mg dose. None of these PDE-5 inhibitors should be used more than once a day. Possible Side Effects Although all three drugs are generally well tolerated, side effects are still possible. Most common side effects: Viagra: facial flushing, headache, indigestion Levitra: facial flushing, headache Cialis: headache, indigestion Less Common Side Effects: Viagra: altered vision, dizziness, nasal, congestion Levitra: indigestion, nausea, dizziness, nasal congestion Cialis: back pain, muscle aches, nasal congestion, facial flushing, dizziness Precautions and Contraindications All PDE-5 inhibitors are absolutely contraindicated in persons who take organic nitrates. Alpha-blockers Viagra has precautionary labeling advising against taking 50 mg or 100 mg doses within four hours of taking a alpha-blocker. The 25 mg dose of Viagra has not been shown to significantly decrease blood pressure and in patients who take 25 mg of Viagra, use of any of the alpha-blockers is considered safe. Levitra is contraindicated in patients taking alpha-blockers. Cialis is contraindicated in patients taking alpha-blockers, except for tamsulosin (Flomax). Since both Viagra and Levitra have moderate vasodilatory and hypotensive effects, they should not be given in the presence of marked arterial or orthostatic hypotension, and should only be administered with caution in aortic stenosis or hypertrophic obstructive cardiomyopathy. Men who have had a heart attack or stroke within the past 6 months and those with certain medical conditions (e.g., uncontrolled high blood pressure, severe low blood pressure or liver disease, unstable angina) that make sexual activity inadvisable should not take Cialis. Dosages of the drug should be limited in patients with kidney or liver disorders. Conclusions The differences between the 3 drugs are not great. All appear to be effective and safe. Levitra has less side effects compared to Viagra and lasts about the same time as Viagra in the body. Cialis has few side effects and lasts longer in the body. This allows increased spontaneity and less frequent dosing than either Levitra or Viagra. However, the longer half-life of Cialis imposes increased risk for drug interactions. pennis enlargement fact pennis enlargement cream penile enlargement cream magna rx pill pennis enlargement surgery picture penis enlargement pills pro solution easy enlargment free penis surgery way vimax easy enlargement free penis surgery way
Most love stories begin with once upon a time there was a charming boy and a beautiful girl. They start dating and they fall in love. So, they decided to marry; marriage held and the consummation of marriage also happened. The first encounter of sex was great, both achieved euphoria. The boy was strong and his enthusiasm was great; he took the girl at the peak of pleasure thrice on the first night. But, after few years the boy lost his libido, not because of he doesn’t like the girl anymore, but because of Erectile Dysfunction (ED). The girl became depressed and unsatisfied lady. This is a small story, which unfortunately is repeated with many of us. During the earlier phase of sexual life, men are highly energetic because in this phase all sex related organs work in a glib manner. But in later phases, ageing degenerates sexual organs, particularly muscles of penis and a man tries to avoid sexual relations. Embarrassment is the feeling which restricts him to be in sexual contact even with his beloved one. Non-arousal of penis is definitely embarrassing when your sexual counterpart is desperate to take you in. How would she feel then; it is a matter of serious concern for a man who loves her by the core of heart. A woman is on the peak sensuality in the later phases of the marriage. Unfortunately, ED dysfunction also occurs when she is willing to play open and rigorously. Erectile dysfunction (ED) doesn’t come suddenly; when it starts, man loses his natural capability of love making gradually. Even if he is frequented with love making twice or thrice a week, ED can reduce it upto twice or thrice in a month. This is definitely inappropriate for a woman who has high libido. The good news is that now there is a solution for this problem. Levitra is the name of a beneficial medication, which can help in erection of penis when erectile dysfunction is there. Levitra’s active ingredient Vardenafil HCl increases the flow of blood in the capillaries of penis by stimulating the secretion of GMP. Secretion of GMP is a natural phenomenon for erection of penis but release of GMP comes down to a lower level with ageing and Levitra brings it back at normal level. Phosphodiesterase-5 is a GMP inhibitor whose secretion generally takes place after achieving orgasm. Whenever erectile dysfunction is there, secretion of PDE-5 takes place much earlier then orgasm. Even if penis is inside the vagina, its release can take place and penis falls back during intercourse. Levitra blocks action of PDE-5, so that erection of penis remains for a long duration, which is generally 4 hours. Levitra is an oral prescription medication, which should be taken only on doctor’s prescription. Levitra might have some mild side effects like chest pain, nausea, dizziness and painful erection. The side-effects are short lived and generally disappear after the use of medication for few days. Levitra pills come in volume of 10mg and 20mg. Generally, doctor prescribes 10mg of Levitra pill swallowed with a glassful of plain water half an hour before having sex. Levitra is easily available through online order and through online purchase, the delivery of Levitra is made at your doorstep. prosolution pnis enlargement pills homemade penis enlarement enlargment manhattan penis penis enhancement surgery vig rx pic safe penis enlargement bottle vimax pills plastic surgery penis enlagement best pennis enlargement surgery
In the man’s body, the pituitary gland in the brain sends a hormone, called follicle-stimulating hormone, (FSH) to the testicles, which are the male sex glands. FSH signals the testicles to produce sperm, which are the male reproductive cells. Sperm are so small they can only be seen through a microscope. Each tiny sperm has a tale that allows it to move. After sperm are produced in the testicles, they travel through a tube called the vas deferens to the seminal vesicle, which holds the mature sperm. A gland called the prostate makes seminal fluid, which is the fluid that will transport the sperm in the urethra. The urethra is a tube that extends from the bladder, through the prostate, then through the penis to the outside of the man’s body. During sexual activity, the prostate gland becomes as full of fluid as it can comfortably hold, and it contracts (squeezes). As the prostate contracts, it draws sperm from the seminal vesicle. Seminal fluid mixed with sperm is called semen. The contractions of the prostate gland force the semen through the urethra and out the tip of the penis. This is called ejaculation. The ejaculate (semen) is a teaspoon to a tablespoon of thick milky liquid and contains millions of microscopic sperm. During sexual activity, but before ejaculation, the penis becomes engorged with blood. This causes the penis to become firm and erect, and is called the male erection. The male erection allows the penis to pass into the vagina of the woman. When a man has an erection a valve closes between the prostate gland and the bladder to prevent urine from being released when semen is ejaculated. Practically speaking, this means that a man cannot urinate and ejaculate at the same time. To begin the reproductive cycle in a woman’s body, a hormone, called follicle-stimulating hormone, (FSH) is produced by the pituitary gland in the brain. FSH travels through the bloodstream to the ovaries, causing a few of the many tiny follicles there to begin ripening, or maturing. Each follicle is a tiny ring of cells with a tiny ovum, or egg, inside. As the follicles ripen, they produce another hormone, called estrogen. Estrogen causes the cervix, the opening of the uterus, to begin making moisture and mucus. This is when a woman notices wetness or mucus outside the vagina. This mucus is not a sign of disease. It is a natural part of the cycle and indicates that the ova are maturing in the ovaries. If intercourse occurs at this time, the mucus will protect the sperm from the acidity of the vagina, assuring that the sperm will still be alive at ovulation. Estrogen also causes the endometrium, the lining of the uterus, to grow soft and spongy, forming a kind of bed that can, in the event of pregnancy, hold and nourish a baby. Finally, estrogen signals the pituitary gland in the brain that some follicles have matured in the ovaries. When the pituitary gland receives the message that some follicles have matured, it produces another hormone, leutenizing hormone, or LH. LH causes one of the ripening follicles to release its ovum into a fallopian tube. This is called ovulation. Once ejaculation has deposited the sperm in the women’s vagina, they swim up the vagina to the uterus. They do not know which fallopian tube may contain the ovum, and so they swim both ways. When a sperm penetrates the ovum, it is called fertilization. Dividing and maturing as it goes, the fertilized ovum is moved slowly along the fallopian tube toward the uterus by the cilia, tiny hairs inside the fallopian tubes. In six or seven days, the fertilized ovum implants in the endometrium (the lining of the uterus), which is the bed that has been created to receive it. Menstruation does not occur, because the fertilized ovum, growing and developing in the uterus, creates hormones that maintain the uterine lining. The woman realizes she has conceived penis enhancement before and after photo real penis elargement vimax penis enlargment pnis enlargement without pills penis elargement tip manual penile enlargment exercise penile enlargement technique truth about pennis enlargement best pennis enlargement surgery
Many nowadays prefer a natural hair loss remedy rather than treat their hair loss with drugs and medication. If you are looking for a natural hair loss remedy for male pattern baldness, you can try saw palmetto. Saw palmetto is a particular type of fruit that has been shown to help in hair loss according to some studies. Having some information about saw palmetto, its use and its benefits can help you decide if this natural hair loss remedy is the type of treatment that you are seeking for. Saw palmetto is a red fruit that grows in warmer climates throughout the world. It is most often seen in South Eastern regions of the United States. Studies into the use of saw palmetto was first done for research on prostate health. However, it was also noticed during the clinical trials that this popular fruit have positive benefits to those with male pattern baldness. Male pattern baldness is a hereditary condition that afflicts more men than women. Hair loss in male pattern baldness is characterized by a receding hairline and that continues in a horseshoe pattern. Hair on the sides and back of the head are mostly unaffected. The exact reason for male pattern baldness is still not very clear. Some studies suggest that excessive conversion of testosterone to another hormone called dihydrotestosterone (DHT) may be an underlying cause. In the studies for prostate health, saw palmetto was shown to block the production of DHT in men suffering from enlargement of the prostate. So how much saw palmetto should you eat for your hair loss? Unverified sources say that if you are eating the fruit, then one per day would in most instances be effective with treating your hair loss. However, if you are taking an extract, then a dosage of three hundred and twenty milligrams per day is recommended. Supplements containing nutrients of saw palmetto are also available to help with hair growth. One of the advantages of taking saw palmetto is that there are no known side effects. This is obviously better than taking synthetic drugs or medication that may have potential adverse results. In fact, these side effects include fast heart rate, headaches, impotence, and decreased libido. Saw palmetto should preferably be taken with other foods or substances. Otherwise, you may end up with a headache or stomachache. In addition, if you observed that you are getting allergic reactions, you should stop consuming saw palmetto immediately. In addition, if you are female and pregnant, then you should not use saw palmetto without medical supervision. Is Saw Palmetto used for Male Pattern Baldness? Currently, there is no known cure for male pattern baldness. Both conventional and natural treatments can help control the hair loss as long as one maintains the treatment. However, once the treatment is discontinued, there is the chance of recurrence. Saw palmetto may be the answer to providing your body with the necessary balance of the hormones and enzymes beneficial for combating hair loss. Do research more into this option if you are looking for a natural hair loss remedy for mild to moderate male pattern baldness. penis enlargement before and after photo penis enlargement surgeries best enlarement exercise penis penis enlargment operation penis enlagement penis enhancement exercise penile enlargment information penis enhancement before and after photo best pennis enlargement surgery
Health has always been the matter of priority and also of concern for people in all walks of life. Because no achievement can spell success and no pleasure can spread happiness if all’s not well with our health. Our body, in addition to physical and psychological well-being also stresses on a good sexual health for the overall personification. But it is a sad fact that millions of men in the world, approximately 35% suffer from sexual dysfunction. Sexual dysfunction in men may be related to various psychological stress factors or lifestyle factors. But the dominant factor is mostly physiological conditions like impotence. Impotence, medically termed erectile dysfunction is the physical condition when a man’s sex organ becomes ineffectual to perform a sexual act, to satisfy his sexual urge or that of his partner. Though recent studies have shown that erectile dysfunction is not age-related and can be treated at any age, the prominent physical cause arteriosclerosis, or the hardening of the arteries are at greater risks in older men. Hardening of penile arteries restricts the free flow of blood thus preventing an erection on sexual arousal. It can also be caused due to chronic diseases like high blood pressure, high cholesterol, diabetes, liver, heart diseases and even obesity. This sexual dysfunction in men which has been the bone of content in the breaking up of many relationships can now be treated by medicinal therapy, most popular as Viagra. Viagra is the pioneer drug in the treatment of erectile dysfunction approved by the FDA in 1998. Although several other drugs in this category has since then been introduced, Viagra has managed to reign supreme in building trust with its consumers; thanks to Pfizer’s publicized marketing skills and its competitive cheaper price. But all credit for the effective values of Viagra can be conferred to its active chemical component – Sildenafil citrate. It works by releasing nitric oxide which helps in relaxing the smooth muscles of the penis, thus improving the flow of blood facilitating an erection. A normal dosage of Viagra taken an hour before sexual activity enhances performance lasting 4 hours. But it is strictly recommended to use Viagra only under prescription from a physician. You can consult your doctor seeking preventive measures against drug interaction and side-effects prior to using Viagra. Moreover, there are innumerable websites providing Viagra online information on the latest studies, research analysis and even free consultation by experts. It has also become easier to buy Viagra from online pharmacies other than over-the-counter pharmacies. Online pharmacies even quote competitive prices but also ‘be wary’ of spurious drugs and buy Viagra only after checking the authenticity of the dealer. In this fast developing world potency guaranteed by Viagra is just a click away. So order Viagra with the click of a mouse in the privacy of your home, and say goodbye to impotence.